The shift in the energy sector toward green resources makes fuel cells increasingly relevant as a supplier of green and sustainable energy. However, factors such as expensive catalysts, anodic poisoning, and fuel crossover reduce the lifetime and performance of the fuel cells, necessitating catalysis improvement. This review article presents the unique capabilities of metal chalcogenides (MC) as tailored catalysts, elucidating their synthesis, testing techniques, and performance evaluations. MC catalysts are matured via various physical and chemical methods to control their morphology, quantity, dimension, and size. Upon synthesis, the catalyst performance is quantified using three-electrode cells, followed by tests in fuel-cell prototypes. As anodic catalysts, MCs oxidize various fuels such as methanol, ethanol, urea, and impure H2 at high current densities and low onset potentials, while hindering the poisoning species. As cathodic catalysts, MCs exhibit current values similar to that exhibited by their noble metal counterparts while reducing oxygen selectively in the vicinity of the fuels via four electron transfers at a wide range of potentials.